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Translational science: drug delivery, tissue engineering, & surgical optimization
Translational science: drug delivery, tissue engineering, & surgical optimization
Motivation: We have experience working with startup companies (Marrow Access Technologies, MechanoTherapeutics, etc.) as well as academic labs in orthopaedics to translate technologies from "bench-to-bedside" in an effort to treat cartilage degeneration and bone pathologies.
Motivation: We have experience working with startup companies (Marrow Access Technologies, MechanoTherapeutics, etc.) as well as academic labs in orthopaedics to translate technologies from "bench-to-bedside" in an effort to treat cartilage degeneration and bone pathologies.
Cell, tissue, & molecule patterning
Cell, tissue, & molecule patterning
Motivation: The tissues within our bodies are more than random clusters of cells. Tissues such as articular cartilage, the knee meniscus, the intervertebral disc, et al. contain patterns of cells and extracellular matrix. These patterns give our tissues unique abilities. After an orthopaedic injury, tissue structure is often disrupted. In some tissues, cells form disorganized scar tissue, and in other tissues, there is no cell response. Regardless, our bodies struggle to heal soft orthopaedic tissues (i.e., cartilage, tendon, intervertebral disc, meniscus, etc.). As engineers we are interested in rebuilding musculoskeletal tissues to mimic their original structures / patterns. To do this in a non-invasive manner, we developed new techniques to pattern cells and cell signaling molecules without exogenous labels. Using the physical properties (i.e., magnetic character, density) of objects, we can tune their positioning in 3D space.
Motivation: The tissues within our bodies are more than random clusters of cells. Tissues such as articular cartilage, the knee meniscus, the intervertebral disc, et al. contain patterns of cells and extracellular matrix. These patterns give our tissues unique abilities. After an orthopaedic injury, tissue structure is often disrupted. In some tissues, cells form disorganized scar tissue, and in other tissues, there is no cell response. Regardless, our bodies struggle to heal soft orthopaedic tissues (i.e., cartilage, tendon, intervertebral disc, meniscus, etc.). As engineers we are interested in rebuilding musculoskeletal tissues to mimic their original structures / patterns. To do this in a non-invasive manner, we developed new techniques to pattern cells and cell signaling molecules without exogenous labels. Using the physical properties (i.e., magnetic character, density) of objects, we can tune their positioning in 3D space.
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